Endocrine Abstracts

Tetrabromobisphenol A (TBBPA) is a brominated flame retardant and is widely used in electronic goods, plastics and furniture. TBBPA is frequently detected in water, soil, organisms and even in human breast milk. It is accessible to both the developing fetus and the nursing pups following maternal exposure. Though some regulatory agencies have asserted that consumer exposures to TBBPA are unlikely to have adverse implications for human health, the safety of TBBPA has been quest...

Mitochondria play an important role in generating energy, and they are essential to cell survival. Mitochondria have varieties of functions, such as regulating intracellular calcium concentration and signal transduction, controlling hormone synthesis, inflammatory responses, and free radicals. In particular this research is interested in the mitochondria in kidney tubular cell. Since mitochondria in tubular cells play an important role in supplying energy, removal of waste and...

Butylparaben is an endocrine disrupting chemical (EDC) which is used as antimicrobial preservative in many cosmetic products. EDCs are structurally diverse class of synthetic and natural compounds. EDCs can cause non-communicable diseases such as obesity, type 2 diabetes, and neurodevelopmental disease. Present study investigated that whether exposure to butylparaben during maternal pregnancy could cause the offspring’s neuronal development disorder. In vitro stu...

Decamethylcyclopentasiloxane (D5) is one of the most common chemical ingredients for daily necessities that can be absorbed through the skin, aerosol, or even orally. People are exposed to D5 daily, but the risk of prenatal exposure to D5 is not completely understood. In this study, the effects of prenatal exposure to D5 on neural development were assessed through behavioral tests on offspring mice. First, the developmental neurotoxicity test (DNT) was performed to determine i...

In our daily life, humans are exposed to lots of chemicals. Among those chemicals, octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) have been widely used in cosmetics for their functions such as softening, wetting, and viscosity control. However, the effect of these chemicals on the female reproductive systems has not been clearly elucidated. In the case of D4, it was recently recognized as an endocrine disrupting chemical (EDC), but the effect of D5 has...

Mitochondria play an important role in generating energy, and they are essential to cell survival. Mitochondria have varieties of functions, such as regulating intracellular calcium concentration and signal transduction, controlling hormone synthesis, inflammatory responses, and free radicals. In particular, this research is interested in the mitochondria in kidney tubular cell. Since mitochondria in tubular cells play an important role in supplying energy, removal of waste an...

The chemically induced disturbance during the neurodevelopment stage could cause a serious disease. In vivo study is useful to discriminate against neurotoxic substances but is time-consuming and ethically problematic. So, we have previously established, developmental neurotoxicity test (DNT) in vitro method using Sox1-GFP. In this study we aimed to increase the predictability of discriminant function. The equation was statistically improved using thirty addi...

Butylparaben is an endocrine disrupting chemical (EDC) which is used as antimicrobial preservative in many cosmetic products. EDCs are structurally diverse class of synthetic and natural compounds. EDCs can cause non-communicable diseases such as obesity, type 2 diabetes, and neurodevelopmental disease. Present study investigated that whether exposure to butylparaben during maternal pregnancy could cause the offspring’s neuronal development disorder. In vitro stu...